Fatty acids, lipotoxicity and insulin secretion
نویسندگان
چکیده
منابع مشابه
Fatty acids and insulin secretion.
It has long been recognized that acute elevation of non-esterified fatty acids (NEFA) stimulates insulin secretion to a moderate extent both in vitro and in vivo. The effects of longer-term exposure to elevated fatty acids have, however, been investigated only recently. Our own studies in the rat have documented the time dependence of NEFA effects, with inhibition of glucose-induced insulin sec...
متن کاملEffects of Free Fatty Acids on Insulin and Glucagon Secretion
Kristinsson, H. 2017. Effects of Free Fatty Acids on Insulin and Glucagon Secretion. – with special emphasis on the role of Free fatty acid receptor 1. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1320. 54 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9867-2. Prevalence of type 2 diabetes mellitus (T2DM) is still rising and even so in the ...
متن کاملn-3 polyunsaturated fatty acids and insulin secretion.
n-3 polyunsaturated fatty acids (PUFAs) are a subgroup of fatty acids with broad health benefits, such as lowering blood triglycerides and decreasing the risk of some types of cancer. A beneficial effect of n-3 PUFAs in diabetes is indicated by results from some studies. Defective insulin secretion is a fundamental pathophysiological change in both types 1 and 2 diabetes. Emerging studies have ...
متن کاملAntagonism Between Saturated and Unsaturated Fatty Acids in ROS Mediated Lipotoxicity in Rat Insulin-Producing Cells.
BACKGROUND/AIMS Elevated levels of non-esterified fatty acids (NEFAs) are under suspicion to mediate β-cell dysfunction and β-cell loss in type 2 diabetes, a phenomenon known as lipotoxicity. Whereas saturated fatty acids show a strong cytotoxic effect upon insulin-producing cells, unsaturated fatty acids are not toxic and can even prevent toxicity. Experimental evidence suggests that oxidative...
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As lactating cows in severe negative energy balance have poor reproductive performance, the effect of dietary fat supplementation (fish oil, soybean oil) on PGFM secretion, ovarian function and blood metabolites is investigated. In this experiment, the effects of dietary polyunsaturated fatty acids on plasma metabolites, ovarian function and prostaglandin secretion of 20 primiparous Holstein co...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1999
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051130